One year has passed since the events described in X-Change. Takuya Aihara has a steady girlfriend named Asuka, and studies at the Miyanomori Private School. Are the nightmares of his past life in a girl's body finally over? Probably not... A chemistry club member Chisato uses Takuya as a guinea pig in an experiment, and as a result he turns into a girl again. Only this time, not only men, but also girls want him!
X-Change 2 is an adult visual novel, featuring more hardcore sex scenes than its predecessor, including lesbian sex. There are 23 possible endings to the game, which the player can attain by making choices presented to him during its course.